Targeted Drug Delivert Proposal for Ataxia-Telangiectasia (A-T)
Aaron Joshua Sun Tolentino
Project Timeline
Apr 2025 - Jul-2025
OVERVIEW
Developed a groundbreaking drug delivery approach that combines blood–brain-barrier–penetrating lipid nanoparticles (LNPs) with antisense oligonucleotides (ASOs) to correct gene splicing errors in ataxia-telangiectasia, presenting one of the first therapeutic strategies with the potential to move beyond symptom management toward a curative treatment for this rare and underserved neurodegenerative disorder.
HighlightS
- Projected a 10% increase in safety and >20% reduction in mortality by benchmarking the proposed system against existing delivery approaches.
- Designed and modeled 5+ nanoparticle release profiles with differential equations, optimizing lipid composition and release rates.
- Achieved ~25% improvement in predicted brain-targeting efficiency through computational optimization of nanoparticle parameters.
SKILLS
Drug TargetingComputational ModelingMolecular TherapeuticsInterdisciplinary Research
ADDITIONAL CONTENTS
Aaron Joshua Sun Tolentino
Mechanical Engineering Graduate | Medical Devices, Manufacturing, Quality, Process Validation
I am a UCLA Mechanical Engineering graduate with expertise in CAD design, 3D printing, and rapid prototyping, skilled in SolidWorks and AutoCAD. At UCLA, I optimized a ceiling-climbing robot, enhancing efficiency and control by integrating research insights into practical design. My experience at WZI and as a Technical Coordinator strengthened my ability to collaborate across disciplines, analyze complex systems, and lead teams toward innovative solutions. I am particularly passionate about medical device R&D, studied in medical imaging and durg delivery, where I can apply my creativity and technical expertise to improve patient outcomes while bringing adaptability and a research-driven mindset to engineering challenges.
I am a UCLA Mechanical Engineering graduate with expertise in CAD design, 3D printing, and rapid prototyping, skilled in SolidWorks and AutoCAD. At UCLA, I optimized a ceiling-climbing robot, enhancing efficiency and control by integrating research insights into practical design. My experience at WZI and as a Technical Coordinator strengthened my ability to collaborate across disciplines, analyze complex systems, and lead teams toward innovative solutions. I am particularly passionate about medical device R&D, studied in medical imaging and durg delivery, where I can apply my creativity and technical expertise to improve patient outcomes while bringing adaptability and a research-driven mindset to engineering challenges.
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